The focus of this handbook is to highlight the key issues in addressing the challenges and opportunities to promote mental health is Sub-Saharan Africa. A unique feature of this work is the privileging of African voices in expressing the strengths, vulnerabilities, and unique approaches which have been found within the Sub-Saharan context. The handbook is broken into three sections. The first introduces the handbook and the general issues and concepts discussed. The second describes diverse community outreach and mental health interventions applied by the contributors in diverse Sub-Saharan Africa countries and contexts and addressing a range of mental health topics. The third focuses on systemic issues that affect mental health service delivery, with recommendations provided. Opportunities for creating new models for sharing practices and disseminating knowledge generated by Sub-Saharan African practitioners for their culture and contexts are discussed.